Background：BLAME (B-lymphocyte activator macrophage expressed) is also known as SLAM family member 8(SLAMF8), CD353.
BLAME is a cell surface receptor that is expressed upon activation of macrophages (MΦs) by IFN-γ or bacteria, is a negative regulator of ROS in response to Gram+ and Gram- bacteria.
May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.
SLAMF8 is a costimulatory molecule that affects the activation of macrophages in inflammation and in immunosuppression and inflammation response to glioma cells could aid immunotherapy for glioma.
仕様
サイズ：25ug
Source：Biotinylated Human BLAME, His,Avitag (BLE-H82E4) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Asp 233 (Accession # Q9P0V8-1).
Molecule：BLAME
Synonyms：BLAME,SLAMF8,CD353
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Ala 23 - Asp 233
Conjugate：Precision Avi
Accession：NP_064510.1
Molecular Weight：27.1 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 27.1 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
