Background：Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.
Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs).
In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells.
CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
仕様
サイズ：25ug
Source：Biotinylated Mouse CD8 alpha, His,Avitag (CDA-M82E8) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Tyr 196 (Accession # P01731-1).
Molecule：CD8 alpha
Synonyms：CD8A,CD8,Leu2,MAL,p32
Species：Mouse
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Lys 28 - Tyr 196
Conjugate：Precision Avi
Accession：NP_001074579.1
Molecular Weight：22.5 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 22.5 kDa. The protein migrates as 34-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
