Background：TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1.
TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA.
Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers.
Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
仕様
サイズ：200ug
Source：Human TROP-2, Fc Tag (TR2-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 274 (Accession # P09758-1).
Molecule：TROP-2
Synonyms：TACSTD2,GA733-1,M1S1,TROP2
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Gln 31 - Thr 274
Conjugate：Unconjugated
Accession：NP_002344.2
Molecular Weight：54.3 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.3 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
