Background：The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure.
We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs.
Siglec-10 was identified through database mining of an asthmatic eosinophil EST library.
The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
仕様
サイズ：25ug
Source：Biotinylated Human Siglec-10, His,Avitag (SI0-H82E3) is expressed from human 293 cells (HEK293). It contains AA Met 17 - Thr 546 (Accession # Q96LC7-1).
Molecule：Siglec-10
Synonyms：SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Met 17 - Thr 546
Conjugate：Precision Avi
Accession：NP_149121.2
Molecular Weight：61.8 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 61.8 kDa. The protein migrates as 65-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
