Background：The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure.
We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs.
Siglec-10 was identified through database mining of an asthmatic eosinophil EST library.
The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
仕様
サイズ：100ug
Source：Mouse Siglec-10, His Tag (SI0-M52H7) is expressed from human 293 cells (HEK293). It contains AA Met 18 - Lys 543 (Accession # Q80ZE3-1).
Molecule：Siglec-10
Synonyms：SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
Species：Mouse
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Met 18 - Lys 543
Conjugate：Unconjugated
Accession：NP_766488.2
Molecular Weight：60.7 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.7 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
