Background：Prominin-1 is also known as CD133, Antigen AC133, PROM1, PROML1 and MSTP061.
Is used as marker for hematopoietic stem and progenitor cells (HSPC) for somatic stem cell isolation.
May play a role in cell differentiation, proliferation and apoptosis .
Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells.
During early retinal development acts as a key regulator of disk morphogenesis.
Involved in regulation of MAPK and Akt signaling pathways.
In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
仕様
サイズ：20ug
Source：Human CD133, His Tag (CD3-H52H4) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - His 865 (Accession # O43490-1).
Molecule：CD133
Synonyms：CD133,PROM1,PROML1,Prominin-1,AC133
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gly 20 - His 865
Conjugate：Unconjugated
Accession：NP_006008.1
Molecular Weight：97.2 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 97.2 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
