Background：MIS RII (Mullerian inhibiting substance type II receptor), also known as AMHRII (anti-Mullerian hormone type II receptor), is a serine/threonine receptor with a single transmembrane domain that belongs to the family of type II receptors of the TGF-beta superfamily.
Mutations in MIS RII result in persistent Mullerian duct syndrome (PMDS), persistent Müllerian duct syndrome (PMDS) is a sex-limited disorder in which males develop portions of the female reproductive tract.
Anti-Müllerian hormone (AMH) and its receptor (AMHR2) induce the regression of the Müllerian ducts in male embryos, but the mechanism by which the Amhr2 gene is specifically activated is not fully understood.
仕様
サイズ：100ug
Source：Human MIS RII, Fc Tag (MII-H5258) is expressed from human 293 cells (HEK293). It contains AA Pro 18 - Ser 144 (Accession # Q16671-1).
Molecule：MIS RII
Synonyms：MIS RII,MRII,AMHR2,AMHR,MISR2,AMH type II receptor
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Pro 18 - Ser 144
Conjugate：Unconjugated
Accession：NP_065434.1
Molecular Weight：40.0 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.0 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
