Background：Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family.
CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
LILRB4 / CD85K is receptor for class I MHC antigens.
CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance.
LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
仕様
サイズ：100ug
Source：Human LILRB4, His Tag (LI4-H52H7) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Glu 259 (Accession # AAH26309.1).
Molecule：LILRB4
Synonyms：LILRB4,ILT3,LIR5,CD85K,HM18
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gln 22 - Glu 259
Conjugate：Unconjugated
Accession：AAH26309.1
Molecular Weight：28.2 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.2 kDa. The protein migrates as 32-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
