Background：Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions.
There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.
仕様
サイズ：100ug
Source：Cynomolgus C5a, Tag Free (C5A-C5118) is expressed from E.coli cells. It contains AA Met 678 - Arg 751 (Accession # XP_015292262.1).
Molecule：Complement Component C5a
Synonyms：C5a,Complement Component 5a
Species：Cynomolgus
Tag：Tag Free
Expression Systems：E.coli
Expression Rigeion：Met 678 - Arg 751
Conjugate：Unconjugated
Accession：XP_015292262.1
Molecular Weight：8.4 kDa
Characteristics：This protein carries no "tag". The protein has a calculated MW of 8.4 kDa. The protein migrates as 11 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
