Background：CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system.
CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells.
The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail.
Alternate splice variants, encoding different isoforms.
CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells.
CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal.
Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
仕様
サイズ：100ug
Source：Rabbit CTLA-4, Fc Tag (CT4-R5250) is expressed from human 293 cells (HEK293). It contains AA Lys 36 - Asp 161 (Accession # P42072).
Molecule：CTLA-4
Synonyms：CTLA4,CD152
Species：Rabbit
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Lys 36 - Asp 161
Conjugate：Unconjugated
Molecular Weight：40.3 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.3 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
