Background：Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant).
LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells.
LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells.
The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
仕様
サイズ：100ug
Source：Human LRRC32, Fc Tag (LR2-H5256) is expressed from human 293 cells (HEK293). It contains AA His 20 - Asn 627 (Accession # Q14392-1).
Molecule：LRRC32
Synonyms：GARP,Garpin,D11S833E
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：His 20 - Asn 627
Conjugate：Unconjugated
Accession：NP_005503.1
Molecular Weight：92.4 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.4 kDa. The protein migrates as 105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
