Background：Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain.
This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells.
Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance.
PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
仕様
サイズ：100ug
Source：Human PD-L1, Llama IgG2b Fc Tag, low endotoxin (PDL-H5250) is expressed from human 293 cells (HEK293). It contains AA Phe 19- Arg 238 (Accession # Q9NZQ7-1).
Molecule：PD-L1
Synonyms：PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1
Species：Human
Tag：Llama IgG Fc Tag
Expression Systems：HEK293
Expression Rigeion：Phe 19- Arg 238
Conjugate：Unconjugated
Accession：NP 054862.1
Molecular Weight：53.0 kDa
Characteristics：This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 53.0 kDa. The protein migrates as 65-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 0.01 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
