Background：Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk.
CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns.
Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases.
The 2 types of cells also cross-regulate the functions of the other.
HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
HAVCR2 regulates macrophage activation.
Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance.
May be also involved in T-cell homing.
Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
仕様
サイズ：100ug
Source：Cynomolgus TIM-3, His Tag (TI3-C52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 201 (Accession # EHH54703.1).
Molecule：TIM-3
Synonyms：HAVCR2,TIM3,TIMD3,FLJ14428,KIM3
Species：Cynomolgus
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Ser 22 - Arg 201
Conjugate：Unconjugated
Accession：EHH54703.1
Molecular Weight：21.6 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.6 kDa. The protein migrates as 30-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
