Background：TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1.
TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA.
Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers.
Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
仕様
サイズ：200ug
Source：Human TROP-2, His Tag (TR2-H5223) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 274 (Accession # P09758-1).
Molecule：TROP-2
Synonyms：TACSTD2,GA733-1,M1S1,TROP2
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gln 31 - Thr 274
Conjugate：Unconjugated
Accession：NP_002344.2
Molecular Weight：29.8 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.8 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
