86-7913-03 ［取扱停止］ActiveMax Human TNF-alpha Protein, Tag Free, low endotoxin (active trimer) (MALS verified) 25ug TNA-H4211
特徴
- Background：Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages.
- It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells.
- TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication.
- Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer.
- Recombinant TNFα is used as an immunostimulant under the INN tasonermin.
- TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
仕様
- サイズ：25ug
- Source：ActiveMax Human TNF-alpha, Tag Free (TNA-H4211) is expressed from human 293 cells (HEK293). It contains AA Val 77 - Leu 233 (Accession # P01375-1).
- Molecule：TNF-alpha
- Synonyms：DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNFα
- Species：Human
- Tag：Tag Free
- Expression Systems：HEK293
- Expression Rigeion：Val 77 - Leu 233
- Conjugate：Unconjugated
- Accession：NP_000585.2
- Molecular Weight：17.4 kDa
- Characteristics：This protein carries no "tag". The protein has a calculated MW of 17.4 kDa. The protein migrates as 17 kDa under reducing (R) condition (SDS-PAGE).
- Endotoxin Level：Less than 0.1 EU per ug by the LAL method.
- Purity：>95% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：25ug*1
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