Background：CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family.
CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose.
These reaction products are essential for the regulation of intracellular Ca2+.
The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications.
The CD38 protein is a marker of cell activation.
It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism.
CD38 has been used as a prognostic marker in leukemia.
仕様
サイズ：50ug
Source：Human CD38, mouse IgG2a Fc Tag, low endotoxin (CD8-H5253) is expressed from human 293 cells (HEK293). It contains AA Val 43 - Ile 300 (Accession # P28907-1).
Molecule：CD38
Synonyms：CD38,T10,cADPr hydrolase 1
Species：Human
Tag：Mouse IgG Fc Tag
Expression Systems：HEK293
Expression Rigeion：Val 43 - Ile 300
Conjugate：Unconjugated
Accession：NP_001766.2
Molecular Weight：56.9 kDa
Characteristics：This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 56.9 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 0.1 EU per ug by the LAL method.
