Background：Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244.
NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains.
CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine.
CD244 interacts with CD48.
Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP.
SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation.
CD244/2B4 is the only heterophilic receptor of SLAM family.
仕様
サイズ：25ug
Source：Biotinylated Human 2B4, Fc,Avitag (2B4-H82F0) is expressed from human 293 cells (HEK293). It contains AA Cys 22 - Arg 221 (Accession # Q9BZW8-2).
Molecule：2B4
Synonyms：CD244,2B4,SLAMF4,NKR2B4,NAIL,h2B4
Species：Human
Tag：Fc Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Cys 22 - Arg 221
Conjugate：Precision Avi
Accession：NP_057466.1
Molecular Weight：50.7 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 50.7 kDa. As a result of glycosylation, the protein migrates as 65-80 kDa under reducing (R) condition, and 130-160 kDa under non-reducing (NR) condition (SDS-PAGE).
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
