Background：Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions.
Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559).
Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton.
The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells.
PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions.
Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
仕様
サイズ：25ug
Source：Biotinylated Human Nectin-3, Fc,Avitag (PV3-H82F3) is expressed from human 293 cells (HEK293). It contains AA Gly 58 - Asp 400 (Accession # Q9NQS3-1).
Molecule：Nectin-3
Synonyms：CD113,Nectin-3,PVRL3
Species：Human
Tag：Fc Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gly 58 - Asp 400
Conjugate：Precision Avi
Accession：NP_056295.1
Molecular Weight：66.1 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 66.1 kDa. The protein migrates as 90-95 kDa and 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
