86-7912-10 ［取扱停止］Biotinylated Human Siglec-3 / CD33 Protein, Avitag,His Tag (MALS verified) 200ug CD3-H82E7
特徴
- Background：Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Iglike lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family.
- Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, one Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.
- CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells.
- In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
- CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
仕様
- サイズ：200ug
- Source：Biotinylated Human Siglec-3, Avitag,His Tag (CD3-H82E7) is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1).
- Molecule：Siglec-3
- Synonyms：CD33,SIGLEC3,gp67
- Species：Human
- Tag：His Tag & Avi Tag
- Expression Systems：HEK293
- Expression Rigeion：Asp 18 - His 259
- Conjugate：Precision Avi
- Accession：AAH28152.1
- Molecular Weight：29.4 kDa
- Characteristics：This protein carries an Avi tag (Avitag) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 29.4 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>95% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：200ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7912-09
Biotinylated Human Siglec-3 / CD33 Protein, Avitag,His Tag (MALS verified) 25ug
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86-7912-10
Biotinylated Human Siglec-3 / CD33 Protein, Avitag,His Tag (MALS verified) 200ug
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