Background：Tyrosine-protein kinase receptor TYRO3 is also known as Tyrosine-protein kinase BYK, DTK, RSE, SKY, TIF, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily.
TYRO3 regulates many physiological processes including cell survival, migration and differentiation.
TYRO3 activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes.
TYRO3 interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 By similarity and also interacts with PIK3R1, this interaction increases PI3-kinase activity.
仕様
サイズ：200ug
Source：Human TYRO3, Fc Tag (TY3-H5251) is expressed from human 293 cells (HEK293). It contains AA Ala 41 - Ser 428 (Accession # AAH51756.1 (Q261H)).
Molecule：TYRO3
Synonyms：TYRO3,BYK,DTK,RSE,SKY,TIF
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Ala 41 - Ser 428
Conjugate：Unconjugated
Accession：AAH51756.1 (Q261H)
Molecular Weight：68.2 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 68.2 kDa. The protein migrates as 86-106 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
