Background：Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily.
TNF-R1 contains one death domain and four TNFR-Cys repeats.
TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha.
The adapter molecule FADD recruits caspase-8 to the activated receptor.
The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).
仕様
サイズ：100ug
Source：Human TNFR1, Fc Tag (TN1-H5251) is expressed from human 293 cells (HEK293). It contains AA Ile 22 - Thr 211 (Accession # NP_001056).
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 47.9 kDa. The protein migrates as 58-66 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>98% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
