86-7911-69 ［取扱停止］Human SMAC / Diablo Protein, His Tag 200ug DIO-H5129
特徴
- Background：Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin.
- Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway.
- Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases.
- Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
仕様
- サイズ：200ug
- Source：Human SMAC, His Tag (DIO-H5129) is expressed from E.coli cells. It contains AA Ala 56 - Asp 239 (Accession # NP_063940).
- Molecule：SMAC
- Synonyms：DIABLO,SMAC
- Species：Human
- Tag：His Tag
- Expression Systems：E.coli
- Expression Rigeion：Ala 56 - Asp 239
- Conjugate：Unconjugated
- Accession：NP_063940
- Molecular Weight：21.7 kDa
- Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.7 kDa. The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE).
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>95% as determined by SDS-PAGE.
- Buffer：20 mM HEPES, 150 mM NaCl, pH7.5
- Package Size：200ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7911-68
Human SMAC / Diablo Protein, His Tag 1mg
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86-7911-69
Human SMAC / Diablo Protein, His Tag 200ug
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