Background：Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC).
PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM.
The complex is then transported across the cell to be secreted at the apical surface.
During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
仕様
サイズ：100ug
Source：Human pIgR, His Tag (PIR-H5222) is expressed from human 293 cells (HEK293). It contains AA Lys 19 - Arg 638 (Accession # AAI10495.1).
Molecule：pIgR
Synonyms：PIGR,Poly-Ig receptor
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Lys 19 - Arg 638
Conjugate：Unconjugated
Accession：AAI10495.1
Molecular Weight：68.7 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 68.7 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
