86-7911-21　［取扱停止］Human PD-1 / PDCD1 Protein, Strep Tag 25ug　PD1-H5284

特徴

• Background：Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators.
• PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes.
• PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family.
• PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ.
• PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines.
• PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.
• In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer.
• In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion.
• Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.