Background：Lumican (LUM) is also known as Keratan sulfate proteoglycan lumican, KSPG lumican,LDC and SLRR2D, which belongs to the small leucine-rich proteoglycan (SLRP) family and SLRP class II subfamily.
LUM /Lumican is present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult.
In the adult cartilage LUM /Lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.
LUM participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation.
The expression of LUM has been correlated to the growth and metastasis of various malignancies.
仕様
サイズ：100ug
Source：Human Lumican, His Tag (LUM-H5227) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Asn 338 (Accession # NP_002336).
Molecule：Lumican
Synonyms：LUM,Lumican,LDC,SLRR2D,KSPG lumican
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Gln 19 - Asn 338
Conjugate：Unconjugated
Accession：NP_002336
Molecular Weight：37.5 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.5 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
