86-7910-89 ［取扱停止］Human Leptin R / CD295 Protein, Fc Tag 100ug LER-H5252
特徴
- Background：Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors.
- Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin.
- LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis.
- Mutations in this protein have been associated with obesity and pituitary dysfunction.
- Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure.
- Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
仕様
- サイズ：100ug
- Source：Human Leptin R, Fc Tag (LER-H5252) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Asp 839 (Accession # NP_002294.2).
- Molecule：Leptin R
- Synonyms：LEPR,CD295,DKFZp686B1731,OBR,Leptin receptor
- Species：Human
- Tag：Fc Tag
- Expression Systems：HEK293
- Expression Rigeion：Phe 22 - Asp 839
- Conjugate：Unconjugated
- Accession：NP_002294.2
- Molecular Weight：119.6 kDa
- Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 119.6 kDa. The protein migrates as 150-165 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>90% as determined by SDS-PAGE.
- Buffer：50 mM Tris, 100 mM Glycine, pH7.5
- Package Size：100ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7910-89
Human Leptin R / CD295 Protein, Fc Tag 100ug
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86-7910-90
Human Leptin R / CD295 Protein, Fc Tag 250ug
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