86-7910-83 ［取扱停止］Human HVEM / TNFRSF14 Protein, Strep Tag 250ug HVM-H5283
特徴
- Background：Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily.
- HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.
- The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD).
- Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM.
- Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer.
- The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
仕様
- サイズ：250ug
- Source：Human HVEM, Strep Tag (HVM-H5283) is expressed from human 293 cells (HEK293). It contains AA Leu 39 - Val 202 (Accession # NP_003811.2).
- Molecule：HVEM
- Synonyms：TNFRSF14,ATAR,HVEA,HVEM,LIGHTR,TR2,CD270
- Species：Human
- Tag：Strep Tag
- Expression Systems：HEK293
- Expression Rigeion：Leu 39 - Val 202
- Conjugate：Unconjugated
- Accession：NP_003811.2
- Molecular Weight：20.4 kDa
- Characteristics：This protein carries a twin strep tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 27-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>90% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：250ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7910-83
Human HVEM / TNFRSF14 Protein, Strep Tag 250ug
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86-7910-84
Human HVEM / TNFRSF14 Protein, Strep Tag 25ug
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