Background：Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains.
DLL4 is expressed in vascular endothelium.
DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4.
DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.
DLL4 can bind to Notch-1 and Notch-4.
仕様
サイズ：100ug
Source：Human DLL4, Fc Tag (DL4-H5259) is expressed from human 293 cells (HEK293). It contains AA Ser 27 - Pro 524 (Accession # NP_061947.1).
Molecule：DLL4
Synonyms：DLL4,Delta4
Species：Human
Tag：Fc Tag
Expression Systems：HEK293
Expression Rigeion：Ser 27 - Pro 524
Conjugate：Unconjugated
Accession：NP_061947.1
Molecular Weight：80.9 kDa
Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 80.9 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
Purity：>95% as determined by SDS-PAGE.
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
