Background：CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system.
CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells.
The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail.
Alternate splice variants, encoding different isoforms.
CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells.
CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal.
Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
仕様
サイズ：100ug
Source：Human CTLA-4, mouse IgG2a Fc tag, low endotoxin (CT4-H52A4) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # NP_005205.2).
Molecule：CTLA-4
Synonyms：CTLA4,CD152
Species：Human
Tag：Mouse IgG Fc Tag
Expression Systems：HEK293
Expression Rigeion：Ala 37 - Phe 162
Conjugate：Unconjugated
Accession：NP_005205.2
Molecular Weight：40.6 kDa
Characteristics：This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 100 kDa under non-reducing (NR) condition.
Endotoxin Level：Less than 0.1 EU per ug by the LAL method.
