86-7910-40 ［取扱停止］Human CTLA-4 / CD152 Protein, Fc Tag (MALS verified) 200ug CT4-H5255
特徴
- Background：CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system.
- CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells.
- The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail.
- Alternate splice variants, encoding different isoforms.
- CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells.
- CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal.
- Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
- Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
仕様
- サイズ：200ug
- Source：Human CTLA-4, Fc Tag (CT4-H5255) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Ser 160 (Accession # NP_005205.2).
- Molecule：CTLA-4
- Synonyms：CTLA4,CD152
- Species：Human
- Tag：Fc Tag
- Expression Systems：HEK293
- Expression Rigeion：Ala 37 - Ser 160
- Conjugate：Unconjugated
- Accession：NP_005205.2
- Molecular Weight：39.9 kDa
- Characteristics：This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.9 kDa. As a result of glycosylation, the protein migrates as 45-55 kDa under reducing (R) condition, and 90 kDa under non-reducing (NR) condition (SDS-PAGE).
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>98% as determined by SDS-PAGE.
- Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
- Package Size：200ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7910-40
Human CTLA-4 / CD152 Protein, Fc Tag (MALS verified) 200ug
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86-7910-39
Human CTLA-4 / CD152 Protein, Fc Tag (MALS verified) 1mg
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