Background：T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3.
CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain.
CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction.
CD4 induces the aggregation of lipid rafts.
CD4 is a primary receptor used by HIV-1 to gain entry into host T cells.
HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.
Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
仕様
サイズ：200ug
Source：Human CD4, His Tag (LE3-H5228) is expressed from human 293 cells (HEK293). It contains AA Lys 26 - Trp 390 (Accession # AAH25782).
Molecule：CD4
Synonyms：CD4,CD4mut,LEU3
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Lys 26 - Trp 390
Conjugate：Unconjugated
Accession：AAH25782
Molecular Weight：41.5 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 41.5 kDa. The protein migrates as 47-54 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
