Background：Disintegrin and metalloproteinase domain-containing protein 8 is also known as ADAM8, Cell surface antigen MS2 and CD antigen CD156a, which belongs to the ADAM (a disintegrin and metalloprotease domain) family.
ADAM family play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction.
ADAM8 / MS2 / CD156a is expressed on neutrophils and monocytes.
ADAM8 / MS2 possible involvement in extravasation of leukocytes.
仕様
サイズ：50ug
Source：Human ADAM8, His Tag (AD8-H5223) is expressed from human 293 cells (HEK293). It contains AA Ile 17 - Pro 497 (Accession # AAI15405.1).
Molecule：ADAM8
Synonyms：ADAM8,MS2,CD156a
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Ile 17 - Pro 497
Conjugate：Unconjugated
Accession：AAI15405.1
Molecular Weight：53.8 kDa
Characteristics：Human ADAM8, His Tag fused with a polyhistidine tag at the C-terminus, has a calculated MW of 53.8 kDa, which migrates as a 130-150 kDa band in DTT-reduced SDS-PAGE due to glycosylation. Two main fragments bands are visible with apparent MW of 58-68 kDa and 35-40 kDa respectively in reduced SDS-PAGE as a result of its being prone to proteolytic cleavage.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
