86-7909-80 ［取扱停止］Cynomolgus / Rhesus macaque CTLA-4 Protein, His Tag 1mg CT4-C5227
特徴
- Background：CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system.
- CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells.
- The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail.
- Alternate splice variants, encoding different isoforms.
- CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells.
- CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal.
- Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
- Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
仕様
- サイズ：1mg
- Source：Cynomolgus / Rhesus macaque CTLA-4, His Tag (CT4-C5227) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Ser 160 (Accession # G7PL88-1). In the region Ala 37 - Ser 160, the AA sequence of Cynomolgus and Rhesus macaque CTLA-4 are homologus.
- Molecule：CTLA-4
- Synonyms：CTLA4,CD152
- Species：Cynomolgus / Rhesus macaque
- Tag：His Tag
- Expression Systems：HEK293
- Expression Rigeion：Ala 37 - Ser 160
- Conjugate：Unconjugated
- Accession：XP_005574071.1
- Molecular Weight：14.1 kDa
- Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.1 kDa. The protein migrates as 19-24 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>95% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：500ug*2
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7909-81
Cynomolgus / Rhesus macaque CTLA-4 Protein, His Tag 200ug
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86-7909-80
Cynomolgus / Rhesus macaque CTLA-4 Protein, His Tag 1mg
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