Background：Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family.
The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family.
The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development.
EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals.
The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth.
Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect.
It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.
仕様
サイズ：25ug
Source：MABSol Biotinylated Human EphB4, His Tag, primary amine labeling (EP4-H8229) is expressed from human HEK293 cells. It contains AA Leu 16 - Ala 539 (Accession # NP_004435.3). It is the biotinylated form of Human EphB4, His Tag (EP4-H5229).
Molecule：EphB4
Synonyms：EphB4,HTK,MYK1,TYRO11
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Leu 16 - Ala 539
Conjugate：UltraLys
Accession：NP_004435.3
Molecular Weight：57.9 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 57.9 kDa. The protein migrates as 62-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
