Background：CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system.
CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells.
The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail.
Alternate splice variants, encoding different isoforms.
CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells.
CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal.
Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
仕様
サイズ：25ug
Source：Biotinylated Cynomolgus / Rhesus macaque CTLA-4, Avitag,His Tag (CT4-C82E5) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Ser 160 (Accession # G7PL88-1). In the region Ala 37 - Ser 160, the AA sequence of Cynomolgus and Rhesus macaque CTLA-4 are homologus.
Molecule：CTLA-4
Synonyms：CTLA4,CD152
Species：Cynomolgus / Rhesus macaque
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Ala 37 - Ser 160
Conjugate：Precision Avi
Accession：XP_005574071.1
Molecular Weight：15.9 kDa
Characteristics：This protein carries an Avi tag (Avitag) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 15.9 kDa. The protein migrates as 20-26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
