Background：domain:The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.,function:Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jup1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.,similarity:Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.,subunit:May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.,
仕様
サイズ：100ul
Source：Rabbit
Applications：WB,ELISA
Species reactivity：Human,Mouse,Rat
Immunogen：The antiserum was produced against synthesized peptide derived from human TNFAIP8L2. AA range:11-60
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
