Background：developmental stage:Expressed at high levels in the fetal liver, lung and kidney.,function:Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.,induction:By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.,similarity:Belongs to the TNFAIP8 family.,tissue specificity:Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.,
仕様
サイズ：100ul
Source：Rabbit
Applications：WB,IHC-p,IF,ELISA
Species reactivity：Human,Mouse
Immunogen：The antiserum was produced against synthesized peptide derived from human TFIP8. AA range:31-80
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
