Background：disease:Antibodies against post-translationally modified DPYSL4, also called anti-CV2 autoantibodies, are present in sera from patients with paraneoplastic neurological diseases (PND). PND are disorders of the nervous system associated with various systemic cancers which are not a direct result of the tumor mass or metastasis, but attributed to remote effects of the cancer.,function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1.,
仕様
サイズ：100ul
Source：Rabbit
Applications：WB,ELISA
Species reactivity：Human,Mouse,Rat
Immunogen：The antiserum was produced against synthesized peptide derived from human DPYSL4. AA range:91-140
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
