86-7785-29　［取扱停止］PKD1 Polyclonal Antibody 100ul　ES10021

特徴

• Background：polycystin 1, transient receptor potential channel interacting(PKD1) Homo sapiens This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on c

仕様

• サイズ：100ul
• Source：Rabbit
• Applications：IHC-p
• Species reactivity：Human
• Immunogen：Synthesized peptide derived from human protein . at AA range: 1370-1450
• Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration：1 mg/ml
• Observed band：473
• GeneID（Human）：PKD1
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