特徴
- Background：The Fas associated via death domain encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
仕様
- サイズ：100ul
- Source：Rabbit
- Applications：WB,IHC-p,ELISA
- Species reactivity：Mouse
- Immunogen：Synthesized peptide derived from FADD . at AA range: 130-210
- Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration：1 mg/ml
- Observed band：30
- GeneID（Human）：FADD
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- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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86-7716-03
FADD Polyclonal Antibody 100ul
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86-7715-91
FADD Polyclonal Antibody 100ul
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86-7716-02
FADD Polyclonal Antibody 100ul
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掲載カタログ情報
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