86-5943-97　［取扱停止］anti- CD150 antibody（PE conjugated） 100ug　FNab09790

特徴

• Background：CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM
• (signalinglymphocyte activation molecule) orIPO-3. CD150, asingle chain type I transmembrane
• molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells.
• The expression is upregulated upon activation. CD150 expression has been shown to be
• maintained onTh1 but notTh2 clones.Tregulatory cells express a relatively high level of CD150.
• Antibodies against CD150 have been shown to augment IFN-g production byTh1 cells, especially
• when co-stimulated through the TCR. CD150 associates with the src homology
• 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be
• involved in signal transduction. In combination with CD48, CD150 is a useful marker for
• hematopoieticstem cell studies.