Background：Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors(thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes(By similarity).
仕様
サイズ：100ug
Host：Rabbit
Specificity：Human, Mouse, Rat
Clonality：polyclonal
Application：ELISA, WB, IF, IP
Isotype：IgG
Form：liquid
Purification：Immunogen affinity purified
Purity：≥95% as determined by SDS-PAGE
Immunogen：zinc finger and BTB domain containing 7B
