Background：TARBP2 is a component of the RISC loading complex(RLC), also known as the micro-RNA(miRNA) loading complex(miRLC). Within the complex, TARBP2 and DICER1 are required to process precursor miRNAs(pre-miRNA) to mature miRNA and then load them onto EIF2C2/AGO2. It may has a role in the production of short interfering RNAs(siRNAs) from double-stranded RNA(dsRNA) by DICER1. Otherwise, it binds to the HIV-1 TAR RNA that is located in the long terminal repeat(LTR) of HIV-1, and stimulates translation of TAR-containing RNAs.
