Background：Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex(DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases(aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
仕様
サイズ：100ug
Host：Rabbit
Specificity：Human, Mouse
Clonality：polyclonal
Application：ELISA, WB, FC
Isotype：IgG
Form：liquid
Purification：Immunogen affinity purified
Purity：≥95% as determined by SDS-PAGE
Immunogen：tumor necrosis factor receptor superfamily, member 1A
