Background：Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate(PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4)P2)(PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier(ETC)(Probable). Does not have in vitro vesicle-to-membrane remodeling activity(PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R(PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin(Probable). Plays a role in the internalization of EGFR after EGF stimulation(Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent(PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles(ILVs) of the multivesicular body for subsequent lysosomal degradation(Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation(PubMed:24610942). Plays a role in macropinocytosis(PubMed:18854019, PubMed:21048941).
