Background：Solute transporter for tetraethylammonium(TEA), 1-methyl-4-phenylpyridinium(MPP), cimetidine, N-methylnicotinamide(NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin(a new platinum anticancer agent). Able to transport paraquat(PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.
