Background：Hydrolyzes the phosphatidylinositol 4,5-bisphosphate(PIP2) to generate 2 second messenger molecules diacylglycerol(DAG) and inositol 1,4,5-trisphosphate(IP3). DAG mediates the activation of protein kinase C(PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
