Background：Required for G1/S transition. Recruits and stabilizes the origin recognition complex(ORC) onto chromatin during G1 to establish pre-replication complex(preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
仕様
サイズ：100ug
Host：Rabbit
Specificity：Human
Clonality：polyclonal
Application：ELISA, WB
Isotype：IgG
Form：liquid
Purification：Immunogen affinity purified
Purity：≥95% as determined by SDS-PAGE
Immunogen：leucine-rich repeats and WD repeat domain containing 1
