Background：E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic(EGF receptors) and exocytic(HIV-1 viral proteins) cargos(PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens(PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation(xenophagy)(PubMed:23245322, PubMed:25484098).
仕様
サイズ：100ug
Host：Rabbit
Specificity：Human, Mouse
Clonality：polyclonal
Application：ELISA, WB, IHC, IF
Isotype：IgG
Form：liquid
Purification：Immunogen affinity purified
Purity：≥95% as determined by SDS-PAGE
Immunogen：leucine rich repeat and sterile alpha motif containing 1
