86-5891-54　anti- KCNAB1 antibody 100ug　FNab04478

特徴

• Background：Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits(PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits(By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity(By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members(PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels(PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure(PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4(PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6(By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1(PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity(By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity(PubMed:17540341). Has NADPH-dependent aldoketoreductase activity(By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity(By similarity).